Homology modelling, molecular docking, and molecular dynamics simulations reveal the inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase enzyme by Withaferin-A

OBJECTIVE: Present in silico study was carried out to explore the mode of inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase (Ld DHFR-TS) enzyme by Withaferin-A, a withanolide isolated from Withania somnifera. Withaferin-A (WA) is known for its profound multifaceted prope...

Descripción completa

Detalles Bibliográficos
Autores principales: Vadloori, Bharadwaja, Sharath, A. K., Prabhu, N. Prakash, Maurya, Radheshyam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902840/
https://www.ncbi.nlm.nih.gov/pubmed/29661206
http://dx.doi.org/10.1186/s13104-018-3354-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902840/
https://www.ncbi.nlm.nih.gov/pubmed/29661206
http://dx.doi.org/10.1186/s13104-018-3354-1

Ejemplares similares