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Insights Into the Bifunctional Aphidicolan-16-ß-ol Synthase Through Rapid Biomolecular Modeling Approaches

Diterpene synthases catalyze complex, multi-step C-C coupling reactions thereby converting the universal, aliphatic precursor geranylgeranyl diphosphate into diverse olefinic macrocylces that form the basis for the structural diversity of the diterpene natural product family. Since catalytically rel...

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Detalles Bibliográficos
Autores principales: Hirte, Max, Meese, Nicolas, Mertz, Michael, Fuchs, Monika, Brück, Thomas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902962/
https://www.ncbi.nlm.nih.gov/pubmed/29692986
http://dx.doi.org/10.3389/fchem.2018.00101