MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?

BACKGROUND: Targeted therapies are based on exploiting cancer-cell-specific genetic features or phenotypic traits to selectively kill cancer cells while leaving normal cells unaffected. Oxidative stress is a cancer hallmark phenotype. Given that free nucleotide pools are particularly vulnerable to o...

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Detalles Bibliográficos
Autores principales: Abbas, Hussein H. K., Alhamoudi, Kheloud M. H., Evans, Mark D., Jones, George D. D., Foster, Steven S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903006/
https://www.ncbi.nlm.nih.gov/pubmed/29661172
http://dx.doi.org/10.1186/s12885-018-4332-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903006/
https://www.ncbi.nlm.nih.gov/pubmed/29661172
http://dx.doi.org/10.1186/s12885-018-4332-7

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