Valproic Acid Exposure of Pregnant Rats During Organogenesis Disturbs Pancreas Development in Insulin Synthesis and Secretion of the Offspring

Valproic acid (VPA) plays a role in histone modifications that eventually inhibit the activity of histone deacetylase (HDAC), and will affect the expressions of genes Pdx1, Nkx6.1, and Ngn3 during pancreatic organogenesis. This experiment was designed to study the effect of VPA exposure in pregnant...

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Detalles Bibliográficos
Autores principales: Komariah, Komariah, Manalu, Wasmen, Kiranadi, Bambang, Winarto, Adi, Handharyani, Ekowati, Roeslan, M. Orliando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Toxicology 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903136/
https://www.ncbi.nlm.nih.gov/pubmed/29686779
http://dx.doi.org/10.5487/TR.2018.34.2.173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903136/
https://www.ncbi.nlm.nih.gov/pubmed/29686779
http://dx.doi.org/10.5487/TR.2018.34.2.173

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