Atorvastatin Downregulates In Vitro Methyl Methanesulfonate and Cyclophosphamide Alkylation-Mediated Cellular and DNA Injuries

Statins are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, and this class of drugs has been studied as protective agents against DNA damages. Alkylating agents (AAs) are able to induce alkylation in macromolecules, causing DNA damage, as DNA methylation. Our objective was to e...

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Detalles Bibliográficos
Autores principales: Araujo-Lima, Carlos F., Christoni, Larissa S. A., Justo, Graça, Soeiro, Maria N. C., Aiub, Claudia A. F., Felzenszwalb, Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903342/
https://www.ncbi.nlm.nih.gov/pubmed/29849914
http://dx.doi.org/10.1155/2018/7820890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903342/
https://www.ncbi.nlm.nih.gov/pubmed/29849914
http://dx.doi.org/10.1155/2018/7820890

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