Nickel-catalyzed coupling reaction of alkyl halides with aryl Grignard reagents in the presence of 1,3-butadiene: mechanistic studies of four-component coupling and competing cross-coupling reactions

We describe the mechanism, substituent effects, and origins of the selectivity of the nickel-catalyzed four-component coupling reactions of alkyl fluorides, aryl Grignard reagents, and two molecules of 1,3-butadiene that affords a 1,6-octadiene carbon framework bearing alkyl and aryl groups at the 3...

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Detalles Bibliográficos
Autores principales: Iwasaki, Takanori, Fukuoka, Asuka, Yokoyama, Wataru, Min, Xin, Hisaki, Ichiro, Yang, Tao, Ehara, Masahiro, Kuniyasu, Hitoshi, Kambe, Nobuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903371/
https://www.ncbi.nlm.nih.gov/pubmed/29719693
http://dx.doi.org/10.1039/c7sc04675h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903371/
https://www.ncbi.nlm.nih.gov/pubmed/29719693
http://dx.doi.org/10.1039/c7sc04675h

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