TRPV4 inhibition attenuates stretch-induced inflammatory cellular responses and lung barrier dysfunction during mechanical ventilation

Mechanical ventilation is an important tool for supporting critically ill patients but may also exert pathological forces on lung cells leading to Ventilator-Induced Lung Injury (VILI). We hypothesised that inhibition of the force-sensitive transient receptor potential vanilloid (TRPV4) ion channel...

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Detalles Bibliográficos
Autores principales: Pairet, N., Mang, S., Fois, G., Keck, M., Kühnbach, M., Gindele, J., Frick, M., Dietl, P., Lamb, D. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903668/
https://www.ncbi.nlm.nih.gov/pubmed/29664963
http://dx.doi.org/10.1371/journal.pone.0196055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903668/
https://www.ncbi.nlm.nih.gov/pubmed/29664963
http://dx.doi.org/10.1371/journal.pone.0196055

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