PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD–RIG-I–NF-κB axis

Hyperactivation of phosphoinositol 3-kinase (PI3K) has been suggested to be a potential mechanism for endoplasmic reticulum (ER) stress-enhanced airway hyperresponsiveness, and PI3K inhibitors have been examined as asthma therapeutics. However, the regulatory mechanism linking PI3K to ER stress and...

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Detalles Bibliográficos
Autores principales: Kim, Hyun-Kyoung, Lee, Geum-Hwa, Bhattarai, Kashi Raj, Junjappa, Raghu Patil, Lee, Hwa-Young, Handigund, Mallikarjun, Marahatta, Anu, Bhandary, Bidur, Baek, In-Hwan, Pyo, Jae Sung, Kim, Hye-Kyung, Chai, Ok Hee, Kim, Hyung-Ryong, Lee, Yong-Chul, Chae, Han-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903822/
https://www.ncbi.nlm.nih.gov/pubmed/29504610
http://dx.doi.org/10.1038/emm.2017.270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903822/
https://www.ncbi.nlm.nih.gov/pubmed/29504610
http://dx.doi.org/10.1038/emm.2017.270

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