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An incoherent feedforward loop facilitates adaptive tuning of gene expression
We studied adaptive evolution of gene expression using long-term experimental evolution of Saccharomyces cerevisiae in ammonium-limited chemostats. We found repeated selection for non-synonymous variation in the DNA binding domain of the transcriptional activator, GAT1, which functions with the repr...
Autores principales: | Hong, Jungeui, Brandt, Nathan, Abdul-Rahman, Farah, Yang, Ally, Hughes, Tim, Gresham, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903863/ https://www.ncbi.nlm.nih.gov/pubmed/29620523 http://dx.doi.org/10.7554/eLife.32323 |
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