Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation

Failure to precisely repair DNA damage in self-renewing Hematopoietic Stem and early Progenitor Cells (HSPCs) can disrupt normal hematopoiesis and promote leukemogenesis. Although HSPCs are widely considered a target of ionizing radiation (IR)-induced hematopoietic injury, definitive data regarding...

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Detalles Bibliográficos
Autores principales: Biechonski, Shahar, Olender, Leonid, Zipin-Roitman, Adi, Yassin, Muhammad, Aqaqe, Nasma, Marcu-Malina, Victoria, Rall-Scharpf, Melanie, Trottier, Magan, Meyn, M. Stephen, Wiesmüller, Lisa, Beider, Katia, Raz, Yael, Grisaru, Dan, Nagler, Arnon, Milyavsky, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904119/
https://www.ncbi.nlm.nih.gov/pubmed/29666389
http://dx.doi.org/10.1038/s41598-018-24440-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904119/
https://www.ncbi.nlm.nih.gov/pubmed/29666389
http://dx.doi.org/10.1038/s41598-018-24440-w

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