Improved calcium sensor GCaMP-X overcomes the calcium channel perturbations induced by the calmodulin in GCaMP

GCaMP, one popular type of genetically-encoded Ca(2+) indicator, has been associated with various side-effects. Here we unveil the intrinsic problem prevailing over different versions and applications, showing that GCaMP containing CaM (calmodulin) interferes with both gating and signaling of L-type...

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Detalles Bibliográficos
Autores principales: Yang, Yaxiong, Liu, Nan, He, Yuanyuan, Liu, Yuxia, Ge, Lin, Zou, Linzhi, Song, Sen, Xiong, Wei, Liu, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904127/
https://www.ncbi.nlm.nih.gov/pubmed/29666364
http://dx.doi.org/10.1038/s41467-018-03719-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904127/
https://www.ncbi.nlm.nih.gov/pubmed/29666364
http://dx.doi.org/10.1038/s41467-018-03719-6

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