Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults

BACKGROUND: The clearance of cytochrome P450 (CYP) 3A substrates is reported to be reduced with lower age, inflammation and obesity. As it is unknown what the overall influence is of these factors in the case of obese adolescents vs. morbidly obese adults, we studied covariates influencing the clear...

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Detalles Bibliográficos
Autores principales: van Rongen, Anne, Brill, Margreke J. E., Vaughns, Janelle D., Välitalo, Pyry A. J., van Dongen, Eric P. A., van Ramshorst, Bert, Barrett, Jeffrey S., van den Anker, Johannes N., Knibbe, Catherijne A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904241/
https://www.ncbi.nlm.nih.gov/pubmed/28785981
http://dx.doi.org/10.1007/s40262-017-0579-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904241/
https://www.ncbi.nlm.nih.gov/pubmed/28785981
http://dx.doi.org/10.1007/s40262-017-0579-4

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