Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination

Adaptive immune responses require the generation of a diverse repertoire of immunoglobulins (Igs) that can recognize and neutralize a seemingly infinite number of antigens. V(D)J recombination creates the primary Ig repertoire, which subsequently is modified by somatic hypermutation (SHM) and class...

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Detalles Bibliográficos
Autores principales: Nicolas, Laura, Cols, Montserrat, Choi, Jee Eun, Chaudhuri, Jayanta, Vuong, Bao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904731/
https://www.ncbi.nlm.nih.gov/pubmed/29744038
http://dx.doi.org/10.12688/f1000research.13247.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904731/
https://www.ncbi.nlm.nih.gov/pubmed/29744038
http://dx.doi.org/10.12688/f1000research.13247.1

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