Cargando…

Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin–GnRH-III conjugates developed for targeted drug delivery

Gonadotropin releasing hormone-III (GnRH-III), a native isoform of the human GnRH isolated from sea lamprey, specifically binds to GnRH receptors on cancer cells enabling its application as targeting moieties for anticancer drugs. Recently, we reported on the identification of a novel daunorubicin–G...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schuster, Sabine, Biri-Kovács, Beáta, Szeder, Bálint, Farkas, Viktor, Buday, László, Szabó, Zsuzsanna, Halmos, Gábor, Mező, Gábor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2018
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905287/ https://www.ncbi.nlm.nih.gov/pubmed/29719573 http://dx.doi.org/10.3762/bjoc.14.64

Ejemplares similares

Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification
por: Schuster, Sabine, et al.
Publicado: (2018)

Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates
por: Schuster, Sabine, et al.
Publicado: (2022)

In Vivo Tumor Growth Inhibition and Antiangiogenic Effect of Cyclic NGR Peptide-Daunorubicin Conjugates Developed for Targeted Drug Delivery
por: Tripodi, Andrea Angelo Pierluigi, et al.
Publicado: (2019)

Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice
por: Ranđelović, Ivan, et al.
Publicado: (2019)

Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids
por: Lajkó, Eszter, et al.
Publicado: (2018)

Suitability of GnRH Receptors for Targeted Photodynamic Therapy in Head and Neck Cancers
por: Pethő, Lilla, et al.
Publicado: (2019)

Drug targeting to decrease cardiotoxicity – determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells
por: Polgár, Livia, et al.
Publicado: (2018)

Protein Expression Profile of HT-29 Human Colon Cancer Cells after Treatment with a Cytotoxic Daunorubicin-GnRH-III Derivative Bioconjugate
por: Schreier, Verena Natalie, et al.
Publicado: (2014)

Novel Crizotinib–GnRH Conjugates Revealed the Significance of Lysosomal Trapping in GnRH-Based Drug Delivery Systems
por: Murányi, József, et al.
Publicado: (2019)

Apoptotic Effects of Drug Targeting Conjugates Containing Different GnRH Analogs on Colon Carcinoma Cells
por: Lajkó, Eszter, et al.
Publicado: (2019)

Structure–Activity Relationship of HER2 Receptor Targeting Peptide and Its Derivatives in Targeted Tumor Therapy
por: Biri-Kovács, Beáta, et al.
Publicado: (2020)

Improved in vivo antitumor effect of a daunorubicin - GnRH-III bioconjugate modified by apoptosis inducing agent butyric acid on colorectal carcinoma bearing mice
por: Kapuvári, Bence, et al.
Publicado: (2016)

Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding
por: Flanagan, Colleen A., et al.
Publicado: (2017)

The role of GnRH metabolite, GnRH-(1-5), in endometrial cancer
por: Cho-Clark, Madelaine J., et al.
Publicado: (2023)

Melatonin Inhibits GnRH-1, GnRH-3 and GnRH Receptor Expression in the Brain of the European Sea Bass, Dicentrarchus labrax
por: Servili, Arianna, et al.
Publicado: (2013)

Comparison of GnRH Agonist, GnRH Antagonist, and GnRH Antagonist Mild Protocol of Controlled Ovarian Hyperstimulation in Good Prognosis Patients
por: Stimpfel, Martin, et al.
Publicado: (2015)

Gonadotropin-Releasing Hormone (GnRH)/GnRH Receptors and Their Role in the Treatment of Endometriosis
por: Resta, Christina, et al.
Publicado: (2023)

GnRH agonist versus GnRH antagonist in assisted reproduction cycles: oocyte morphology
por: Cota, Ana Marcia M, et al.
Publicado: (2012)

Comparison of long GnRH agonist versus GnRH antagonist protocol in poor responders
por: Şahin, Sadık, et al.
Publicado: (2014)

GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors
por: Sperduti, Samantha, et al.
Publicado: (2019)

Differential Roles of GnRH-I and GnRH-II Neurons in the Control of the Primate Reproductive Axis
por: Urbanski, Henry F.
Publicado: (2012)

GnRH agonist versus GnRH antagonist in in vitro fertilization and embryo transfer (IVF/ET)
por: Depalo, Raffaella, et al.
Publicado: (2012)

Comparacion de la fertilidad con dos protocolos: utilizando GnRH-PGF2a-GnRH y GnRH-PGF2a-estrogenos
por: Santiago Domínguez, Cesar
Publicado: (2010)

Microdose GnRH Agonist Flare-Up versus Ultrashort GnRH Agonist Combined with Fixed GnRH Antagonist in Poor Responders of Assisted Reproductive Techniques Cycles
por: Eftekhar, Maryam, et al.
Publicado: (2013)

Gonadotropin-releasing hormone (GnRH) stimulation test before and after GnRH analogue treatment in central precocious puberty; can GnRH test simplify adequately?
por: Yang, You Jean, et al.
Publicado: (2013)

Effects of Gonadotropin-Releasing Hormone (GnRH) and Its Analogues on the Physiological Behaviors and Hormone Content of Tetrahymena pyriformis
por: Lajkó, Eszter, et al.
Publicado: (2019)

Estrogenic Regulation of the GnRH Neuron
por: Radovick, Sally, et al.
Publicado: (2012)

GnRH–Antagonisten 2.0
por: Felberbaum, Ricardo, et al.
Publicado: (2020)

Mathematical models in GnRH research
por: Voliotis, Margaritis, et al.
Publicado: (2022)

Ovarian stimulation with GnRH analogues
por: Montenegro, Ivan S., et al.
Publicado: (2014)

Cost-effectiveness analysis of GnRH-agonist long-protocol and GnRH-antagonist protocol for in vitro fertilization
por: Jing, Miaomiao, et al.
Publicado: (2020)

Stop GnRH-agonist/GnRH-antagonist protocol: a different insight on ovarian stimulation for IVF
por: Orvieto, Raoul
Publicado: (2023)

Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocols
por: Yang, Wen-Jui, et al.
Publicado: (2009)

Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice
por: Wang, Li, et al.
Publicado: (2020)

Divergent expression patterns of pituitary gonadotropin subunit and GnRH receptor genes to continuous GnRH in vitro and in vivo
por: Janjic, Marija M., et al.
Publicado: (2019)

A Flexible Multidose GnRH Antagonist versus a Microdose Flare-Up GnRH Agonist Combined with a Flexible Multidose GnRH Antagonist Protocol in Poor Responders to IVF
por: Turgay Çelik, Gayem İnayet, et al.
Publicado: (2015)

GnRH analogues in cancer and human reproduction /
Publicado: (1989)

GnRH Antagonist IVF Protocol in PCOS
por: Onofriescu, Alina, et al.
Publicado: (2013)

Hypothalamic inflammation and GnRH in aging development
por: Tang, Yizhe, et al.
Publicado: (2013)

The role of GABA in the regulation of GnRH neurons
por: Watanabe, Miho, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_7gsqfq5jcl462h455ub6drffgk