Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase

The Retinoblastoma 1 (RB1) tumor suppressor, a member of the Retinoblastoma gene family, functions as a pocket protein for the functional binding of E2F transcription factors. About 1/3 of retinoblastoma patients harbor a germline RB1 mutation or deletion, leading to the development of retinoblastom...

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Detalles Bibliográficos
Autores principales: Tu, Jian, Huo, Zijun, Liu, Mo, Wang, Donghui, Xu, An, Zhou, Ruoji, Zhu, Dandan, Gingold, Julian, Shen, Jingnan, Zhao, Ruiying, Lee, Dung-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905711/
https://www.ncbi.nlm.nih.gov/pubmed/29414415
http://dx.doi.org/10.1016/j.scr.2018.01.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905711/
https://www.ncbi.nlm.nih.gov/pubmed/29414415
http://dx.doi.org/10.1016/j.scr.2018.01.021

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