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Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase
The Retinoblastoma 1 (RB1) tumor suppressor, a member of the Retinoblastoma gene family, functions as a pocket protein for the functional binding of E2F transcription factors. About 1/3 of retinoblastoma patients harbor a germline RB1 mutation or deletion, leading to the development of retinoblastom...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905711/ https://www.ncbi.nlm.nih.gov/pubmed/29414415 http://dx.doi.org/10.1016/j.scr.2018.01.021 |