P2RY1/ALK3-Expressing Cells within the Adult Human Exocrine Pancreas Are BMP-7 Expandable and Exhibit Progenitor-like Characteristics

Treatment of human pancreatic non-endocrine tissue with Bone Morphogenetic Protein 7 (BMP-7) leads to the formation of glucose-responsive β-like cells. Here, we show that BMP-7 acts on extrainsular cells expressing PDX1 and the BMP receptor activin-like kinase 3 (ALK3/BMPR1A). In vitro lineage traci...

Descripción completa

Detalles Bibliográficos
Autores principales: Qadir, Mirza Muhammad Fahd, Álvarez-Cubela, Silvia, Klein, Dagmar, Lanzoni, Giacomo, García-Santana, Carlos, Montalvo, Abelardo, PlÁceres-Uray, Fabiola, Mazza, Emilia Maria Cristina, Ricordi, Camillo, Inverardi, Luca Alessandro, Pastori, Ricardo Luis, Domínguez-Bendala, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905712/
https://www.ncbi.nlm.nih.gov/pubmed/29490276
http://dx.doi.org/10.1016/j.celrep.2018.02.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905712/
https://www.ncbi.nlm.nih.gov/pubmed/29490276
http://dx.doi.org/10.1016/j.celrep.2018.02.006

Ejemplares similares