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Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9
[Image: see text] CRISPR-Cas9 is a genome editing technology with major impact in life sciences. In this system, the endonuclease Cas9 generates double strand breaks in DNA upon RNA-guided recognition of a complementary DNA sequence, which strictly requires the presence of a protospacer adjacent mot...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905990/ https://www.ncbi.nlm.nih.gov/pubmed/28764328 http://dx.doi.org/10.1021/jacs.7b05313 |