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Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9

[Image: see text] CRISPR-Cas9 is a genome editing technology with major impact in life sciences. In this system, the endonuclease Cas9 generates double strand breaks in DNA upon RNA-guided recognition of a complementary DNA sequence, which strictly requires the presence of a protospacer adjacent mot...

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Detalles Bibliográficos
Autores principales:	Palermo, Giulia, Ricci, Clarisse G., Fernando, Amendra, Basak, Rajshekhar, Jinek, Martin, Rivalta, Ivan, Batista, Victor S., McCammon, J. Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905990/ https://www.ncbi.nlm.nih.gov/pubmed/28764328 http://dx.doi.org/10.1021/jacs.7b05313

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