A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models

Tumor suppressor p53 prevents early death due to cancer development. However, the role of p53 in aging process and longevity has not been well-established. In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele...

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Detalles Bibliográficos
Autores principales: Zhao, Yuhan, Wu, Lihua, Yue, Xuetian, Zhang, Cen, Wang, Jianming, Li, Jun, Sun, Xiaohui, Zhu, Yiming, Feng, Zhaohui, Hu, Wenwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906094/
https://www.ncbi.nlm.nih.gov/pubmed/29557783
http://dx.doi.org/10.7554/eLife.34701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906094/
https://www.ncbi.nlm.nih.gov/pubmed/29557783
http://dx.doi.org/10.7554/eLife.34701

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