APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

The TP53 tumor suppressor gene is frequently inactivated in human tumors by missense mutations in the DNA binding domain. TP53 mutations lead to protein unfolding, decreased thermostability and loss of DNA binding and transcription factor function. Pharmacological targeting of mutant p53 to restore...

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Detalles Bibliográficos
Autores principales: Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906465/
https://www.ncbi.nlm.nih.gov/pubmed/29670092
http://dx.doi.org/10.1038/s41419-018-0463-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906465/
https://www.ncbi.nlm.nih.gov/pubmed/29670092
http://dx.doi.org/10.1038/s41419-018-0463-7

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