Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein

Tau antibodies have shown therapeutic potential for Alzheimer’s disease and several are in clinical trials. As a microtubule-associated protein, tau relies on dynamic phosphorylation for its normal functions. In tauopathies, it becomes hyperphosphorylated and aggregates into toxic assemblies, which...

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Detalles Bibliográficos
Autores principales: Chukwu, Jessica E., Pedersen, Jan T., Pedersen, Lars Ø., Volbracht, Christiane, Sigurdsson, Einar M., Kong, Xiang-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906480/
https://www.ncbi.nlm.nih.gov/pubmed/29670132
http://dx.doi.org/10.1038/s41598-018-24276-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906480/
https://www.ncbi.nlm.nih.gov/pubmed/29670132
http://dx.doi.org/10.1038/s41598-018-24276-4

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