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Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein

Tau antibodies have shown therapeutic potential for Alzheimer’s disease and several are in clinical trials. As a microtubule-associated protein, tau relies on dynamic phosphorylation for its normal functions. In tauopathies, it becomes hyperphosphorylated and aggregates into toxic assemblies, which...

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Detalles Bibliográficos
Autores principales:	Chukwu, Jessica E., Pedersen, Jan T., Pedersen, Lars Ø., Volbracht, Christiane, Sigurdsson, Einar M., Kong, Xiang-Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906480/ https://www.ncbi.nlm.nih.gov/pubmed/29670132 http://dx.doi.org/10.1038/s41598-018-24276-4

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