Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis

ATM drives DNA repair by phosphorylating the histone variant H2AX. While ATM mutations elicit prominent neurobehavioral phenotypes, neural roles for H2AX have been elusive. We report impaired motor learning and balance in H2AX-deficient mice. Mitigation of reactive oxygen species (ROS) with N-acetyl...

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Detalles Bibliográficos
Autores principales: Weyemi, Urbain, Paul, Bindu D., Snowman, Adele M., Jailwala, Parthav, Nussenzweig, Andre, Bonner, William M., Snyder, Solomon H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906610/
https://www.ncbi.nlm.nih.gov/pubmed/29670103
http://dx.doi.org/10.1038/s41467-018-03948-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906610/
https://www.ncbi.nlm.nih.gov/pubmed/29670103
http://dx.doi.org/10.1038/s41467-018-03948-9

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