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Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
ATM drives DNA repair by phosphorylating the histone variant H2AX. While ATM mutations elicit prominent neurobehavioral phenotypes, neural roles for H2AX have been elusive. We report impaired motor learning and balance in H2AX-deficient mice. Mitigation of reactive oxygen species (ROS) with N-acetyl...
Autores principales: | Weyemi, Urbain, Paul, Bindu D., Snowman, Adele M., Jailwala, Parthav, Nussenzweig, Andre, Bonner, William M., Snyder, Solomon H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906610/ https://www.ncbi.nlm.nih.gov/pubmed/29670103 http://dx.doi.org/10.1038/s41467-018-03948-9 |
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