Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation

Seipin gene is originally found in type 2 congenital generalized lipodystrophy (CGL2) to involve lipid droplet formation. Recently, decrease of seipin expression is reported in substantia nigra of Parkinson’s disease patients. Dopaminergic neurons in substantia nigra pars compacta expressed the seip...

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Detalles Bibliográficos
Autores principales: Wang, Ling, Hong, Juan, Wu, Yajuan, Liu, George, Yu, Wenfeng, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906676/
https://www.ncbi.nlm.nih.gov/pubmed/29670081
http://dx.doi.org/10.1038/s41419-018-0471-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906676/
https://www.ncbi.nlm.nih.gov/pubmed/29670081
http://dx.doi.org/10.1038/s41419-018-0471-7

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