Restoring functional neurofibromin by protein transduction

In Neurofibromatosis 1 (NF1) germ line loss of function mutations result in reduction of cellular neurofibromin content (NF1+/−, NF1 haploinsufficiency). The Ras-GAP neurofibromin is a very large cytoplasmic protein (2818 AA, 319 kDa) involved in the RAS-MAPK pathway. Aside from regulation of prolif...

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Detalles Bibliográficos
Autores principales: Mellert, K., Lechner, S., Lüdeke, M., Lamla, M., Möller, P., Kemkemer, R., Scheffzek, K., Kaufmann, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906691/
https://www.ncbi.nlm.nih.gov/pubmed/29670214
http://dx.doi.org/10.1038/s41598-018-24310-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906691/
https://www.ncbi.nlm.nih.gov/pubmed/29670214
http://dx.doi.org/10.1038/s41598-018-24310-5

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