Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers

Tissue-specific driver mutations in non-coding genomic regions remain undefined for most cancer types. Here, we unbiasedly analyze 212 gastric cancer (GC) whole genomes to identify recurrently mutated non-coding regions in GC. Applying comprehensive statistical approaches to accurately model backgro...

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Detalles Bibliográficos
Autores principales: Guo, Yu Amanda, Chang, Mei Mei, Huang, Weitai, Ooi, Wen Fong, Xing, Manjie, Tan, Patrick, Skanderup, Anders Jacobsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906695/
https://www.ncbi.nlm.nih.gov/pubmed/29670109
http://dx.doi.org/10.1038/s41467-018-03828-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906695/
https://www.ncbi.nlm.nih.gov/pubmed/29670109
http://dx.doi.org/10.1038/s41467-018-03828-2

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