Simvastatin Enhances Activity and Trafficking of α7 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways

Simvastatin (SV) enhances glutamate release and synaptic plasticity in hippocampal CA1 region upon activation of α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we examined the effects of SV on the functional activity of α7nAChR on CA1 pyramidal cells using patch-clamp recording and ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Tingting, Wang, Ya, Zhang, Tingting, Zhang, Baofeng, Chen, Lei, Zhao, Liandong, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906710/
https://www.ncbi.nlm.nih.gov/pubmed/29706890
http://dx.doi.org/10.3389/fphar.2018.00362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906710/
https://www.ncbi.nlm.nih.gov/pubmed/29706890
http://dx.doi.org/10.3389/fphar.2018.00362

Ejemplares similares