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Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K(+) channel activator NS3623

Transient outward potassium current (I(to)) contributes to early repolarization of many mammalian cardiac action potentials, including human, whilst the rapid delayed rectifier K(+) current (I(Kr)) contributes to later repolarization. Fast I(to) channels can be produced from the Shal family KCNDE ge...

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Detalles Bibliográficos
Autores principales: Lainez, Sergio, Doray, Adélaïde, Hancox, Jules C., Cannell, Mark B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906734/
https://www.ncbi.nlm.nih.gov/pubmed/29378180
http://dx.doi.org/10.1016/j.bcp.2018.01.036