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Annotating activation/inhibition relationships to protein-protein interactions using gene ontology relations
BACKGROUND: Signaling pathways can be reconstructed by identifying ‘effect types’ (i.e. activation/inhibition) of protein-protein interactions (PPIs). Effect types are composed of ‘directions’ (i.e. upstream/downstream) and ‘signs’ (i.e. positive/negative), thereby requiring directions as well as si...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907154/ https://www.ncbi.nlm.nih.gov/pubmed/29671402 http://dx.doi.org/10.1186/s12918-018-0535-4 |