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Discovery of Boolean metabolic networks: integer linear programming based approach
BACKGROUND: Traditional drug discovery methods focused on the efficacy of drugs rather than their toxicity. However, toxicity and/or lack of efficacy are produced when unintended targets are affected in metabolic networks. Thus, identification of biological targets which can be manipulated to produc...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907190/ https://www.ncbi.nlm.nih.gov/pubmed/29671395 http://dx.doi.org/10.1186/s12918-018-0528-3 |