Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study

I(Kr) is the rapidly activating component of the delayed rectifier potassium current, the ion current largely responsible for the repolarization of the cardiac action potential. Inherited forms of long QT syndrome (LQTS) (Lees-Miller et al., 1997) in humans are linked to functional modifications in...

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Detalles Bibliográficos
Autores principales: Perissinotti, Laura L., De Biase, Pablo M., Guo, Jiqing, Yang, Pei-Chi, Lee, Miranda C., Clancy, Colleen E., Duff, Henry J., Noskov, Sergei Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907531/
https://www.ncbi.nlm.nih.gov/pubmed/29706893
http://dx.doi.org/10.3389/fphys.2018.00207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907531/
https://www.ncbi.nlm.nih.gov/pubmed/29706893
http://dx.doi.org/10.3389/fphys.2018.00207

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