Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients

BACKGROUND: Thiazide and thiazide‐like diuretics are first‐line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with incompletely understood mechanisms. Our goal was to...

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Detalles Bibliográficos
Autores principales: Singh, Sonal, McDonough, Caitrin W., Gong, Yan, Alghamdi, Wael A., Arwood, Meghan J., Bargal, Salma A., Dumeny, Leanne, Li, Wen‐Yi, Mehanna, Mai, Stockard, Bradley, Yang, Guang, de Oliveira, Felipe A., Fredette, Natalie C., Shahin, Mohamed H., Bailey, Kent R., Beitelshees, Amber L., Boerwinkle, Eric, Chapman, Arlene B., Gums, John G., Turner, Stephen T., Cooper‐DeHoff, Rhonda M., Johnson, Julie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907544/
https://www.ncbi.nlm.nih.gov/pubmed/29523524
http://dx.doi.org/10.1161/JAHA.117.007339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907544/
https://www.ncbi.nlm.nih.gov/pubmed/29523524
http://dx.doi.org/10.1161/JAHA.117.007339

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