Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors

Successful medicinal chemistry campaigns to discover and optimize sphingosine kinase inhibitors require a robust assay for screening chemical libraries and for determining rank order potencies. Existing assays for these enzymes are laborious, expensive and/or low throughput. The toxicity of excessiv...

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Detalles Bibliográficos
Autores principales: Kharel, Yugesh, Agah, Sayeh, Huang, Tao, Mendelson, Anna J., Eletu, Oluwafunmilayo T., Barkey-Bircann, Peter, Gesualdi, James, Smith, Jeffrey S., Santos, Webster L., Lynch, Kevin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908134/
https://www.ncbi.nlm.nih.gov/pubmed/29672528
http://dx.doi.org/10.1371/journal.pone.0192179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908134/
https://www.ncbi.nlm.nih.gov/pubmed/29672528
http://dx.doi.org/10.1371/journal.pone.0192179

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