Functional relevance of in vivo half antibody exchange of an IgG4 therapeutic antibody-drug conjugate

An increasing number of monoclonal antibodies and derivatives such as antibody-drug conjugates (ADC) are of the IgG1 and IgG4 isotype with distinct structural and functional properties. In cases where antibody-mediated cytotoxicity is not desired, IgG4 is often used, as its Fc region is relatively p...

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Detalles Bibliográficos
Autores principales: Herbener, Peter, Schönfeld, Kurt, König, Martin, Germer, Matthias, Przyborski, Jude M., Bernöster, Katrin, Schüttrumpf, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908158/
https://www.ncbi.nlm.nih.gov/pubmed/29672587
http://dx.doi.org/10.1371/journal.pone.0195823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908158/
https://www.ncbi.nlm.nih.gov/pubmed/29672587
http://dx.doi.org/10.1371/journal.pone.0195823

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