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A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines
Practice-changing culturing techniques of hepatocytes are highly required to increase their differentiation. Previously, we found that human liver cell lines HepaRG and C3A acquire higher functionality and increased mitochondrial biogenesis when cultured in the AMC-Bioartificial liver (BAL). Dynamic...
Autores principales: | Adam, Aziza A. A., van der Mark, Vincent A., Donkers, Joanne M., Wildenberg, Manon E., Oude Elferink, Ronald P. J., Chamuleau, Robert A. F. M., Hoekstra, Ruurdtje |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908182/ https://www.ncbi.nlm.nih.gov/pubmed/29672606 http://dx.doi.org/10.1371/journal.pone.0193664 |
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