Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

Somatic mutations in DNMT3A are recurrent events across a range of blood cancers. Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self-renewal at the expense of differentiation. Moreover, DNMT3A mutations can be detected in the blood of aging individuals, indicating...

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Detalles Bibliográficos
Autores principales: Jeong, Mira, Park, Hyun Jung, Celik, Hamza, Ostrander, Elizabeth L., Reyes, Jaime M., Guzman, Anna, Rodriguez, Benjamin, Lei, Yong, Lee, Yeojin, Ding, Lei, Guryanova, Olga A., Li, Wei, Goodell, Margaret A., Challen, Grant A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908249/
https://www.ncbi.nlm.nih.gov/pubmed/29617651
http://dx.doi.org/10.1016/j.celrep.2018.03.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908249/
https://www.ncbi.nlm.nih.gov/pubmed/29617651
http://dx.doi.org/10.1016/j.celrep.2018.03.025

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