Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy

Aberrant activation and interactions of hedgehog (HH) and PI3K/AKT/mTOR signaling pathways are frequently associated with high-risk medulloblastoma (MB). Thus, combined targeting of the HH and PI3K/AKT/mTOR pathways could be a viable therapeutic strategy to treat high-risk patients. Therefore, we in...

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Detalles Bibliográficos
Autores principales: Chaturvedi, Nagendra K., Kling, Matthew J., Coulter, Don W., McGuire, Timothy R., Ray, Sutapa, Kesherwani, Varun, Joshi, Shantaram S., Sharp, J. Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908274/
https://www.ncbi.nlm.nih.gov/pubmed/29682173
http://dx.doi.org/10.18632/oncotarget.24618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908274/
https://www.ncbi.nlm.nih.gov/pubmed/29682173
http://dx.doi.org/10.18632/oncotarget.24618

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