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The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity
Histone methylation is regulated to shape the epigenome by modulating DNA compaction, thus playing central roles in fundamental chromatin-based processes including transcriptional regulation, DNA repair and cell proliferation. Histone methylation is erased by demethylases including the well-establis...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908291/ https://www.ncbi.nlm.nih.gov/pubmed/29682190 http://dx.doi.org/10.18632/oncotarget.24717 |