A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia

Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is one of the most common genetic lesions in acute myeloid leukemia patients (AML). Although FLT3 tyrosine kinase inhibitors initially exhibit clinical activity, resistance to treatment inevitably occurs within months. PIM kinases are...

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Detalles Bibliográficos
Autores principales: Czardybon, Wojciech, Windak, Renata, Gołas, Aniela, Gałęzowski, Michał, Sabiniarz, Aleksandra, Dolata, Izabela, Salwińska, Magdalena, Guzik, Paweł, Zawadzka, Magdalena, Gabor-Worwa, Ewelina, Winnik, Bożena, Żurawska, Małgorzata, Kolasińska, Ewa, Wincza, Ewelina, Bugaj, Marta, Danielewicz, Monika, Majewska, Eliza, Mazan, Milena, Dubin, Grzegorz, Noyszewska-Kania, Monika, Jabłońska, Ewa, Szydłowski, Maciej, Sewastianik, Tomasz, Puła, Bartosz, Szumera-Ciećkiewicz, Anna, Prochorec-Sobieszek, Monika, Mądro, Elżbieta, Lech-Marańda, Ewa, Warzocha, Krzysztof, Tamburini, Jerome, Juszczyński, Przemysław, Brzózka, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908295/
https://www.ncbi.nlm.nih.gov/pubmed/29682194
http://dx.doi.org/10.18632/oncotarget.24747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908295/
https://www.ncbi.nlm.nih.gov/pubmed/29682194
http://dx.doi.org/10.18632/oncotarget.24747

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