Development of a quantitative pharmacodynamic assay for apoptosis in fixed tumor tissue and its application in distinguishing cytotoxic drug—induced DNA double strand breaks from DNA double strand breaks associated with apoptosis

DNA double strand breaks (DSBs) induced by cancer therapeutic agents can lead to DNA damage repair or persistent DNA damage, which can induce apoptotic cell death; however, apoptosis also induces DSBs independent of genotoxic insult. γH2AX is an established biomarker for DSBs but cannot distinguish...

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Detalles Bibliográficos
Autores principales: Dull, Angie B., Wilsker, Deborah, Hollingshead, Melinda, Mazcko, Christina, Annunziata, Christina M., LeBlanc, Amy K., Doroshow, James H., Kinders, Robert J., Parchment, Ralph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908309/
https://www.ncbi.nlm.nih.gov/pubmed/29682208
http://dx.doi.org/10.18632/oncotarget.24936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908309/
https://www.ncbi.nlm.nih.gov/pubmed/29682208
http://dx.doi.org/10.18632/oncotarget.24936

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