Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Class B peptide hormone GPCRs are targets for the treatment of major chronic disease. Peptide ligands of these receptors display biased agonism and this may provide future therapeutic advantage. Recent active structures of the calcitonin (CT) and glucagon-like peptide-1 (GLP-1) receptors reveal dist...

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Detalles Bibliográficos
Autores principales: Dal Maso, Emma, Zhu, Yue, Pham, Vi, Reynolds, Christopher A., Deganutti, Giuseppe, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Wang, Ming-Wei, Sexton, Patrick M., Furness, Sebastian G.B., Wootten, Denise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908784/
https://www.ncbi.nlm.nih.gov/pubmed/29454620
http://dx.doi.org/10.1016/j.bcp.2018.02.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908784/
https://www.ncbi.nlm.nih.gov/pubmed/29454620
http://dx.doi.org/10.1016/j.bcp.2018.02.005

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