Cargando…

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Class B peptide hormone GPCRs are targets for the treatment of major chronic disease. Peptide ligands of these receptors display biased agonism and this may provide future therapeutic advantage. Recent active structures of the calcitonin (CT) and glucagon-like peptide-1 (GLP-1) receptors reveal dist...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dal Maso, Emma, Zhu, Yue, Pham, Vi, Reynolds, Christopher A., Deganutti, Giuseppe, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Wang, Ming-Wei, Sexton, Patrick M., Furness, Sebastian G.B., Wootten, Denise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908784/ https://www.ncbi.nlm.nih.gov/pubmed/29454620 http://dx.doi.org/10.1016/j.bcp.2018.02.005

Ejemplares similares

Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors
por: Deganutti, Giuseppe, et al.
Publicado: (2021)

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas
por: Ostrovskaya, Anna, et al.
Publicado: (2019)

Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias
por: Andreassen, Kim Vietz, et al.
Publicado: (2014)

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor
por: Wootten, Denise, et al.
Publicado: (2016)

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism
por: Wootten, Denise, et al.
Publicado: (2016)

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
por: Deganutti, Giuseppe, et al.
Publicado: (2022)

Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening
por: Coudrat, Thomas, et al.
Publicado: (2017)

Structure and dynamics of the active Gs-coupled human secretin receptor
por: Dong, Maoqing, et al.
Publicado: (2020)

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
por: Liang, Yi-Lynn, et al.
Publicado: (2018)

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling
por: Coudrat, Thomas, et al.
Publicado: (2017)

Understanding VPAC receptor family peptide binding and selectivity
por: Piper, Sarah J., et al.
Publicado: (2022)

A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene‐related peptide and beyond
por: Garelja, Michael L., et al.
Publicado: (2022)

Editorial: Calcitonin Gene-Related Peptide: Novel Biology and Treatments
por: Brain, Susan D., et al.
Publicado: (2022)

Calcitonin/Amylin Receptors and Ramps
por: Sexton, Patrick M.
Publicado: (2001)

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol
por: Harikumar, Kaleeckal G., et al.
Publicado: (2021)

Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors
por: Lee, Sangmin
Publicado: (2021)

Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function
por: Barwell, James, et al.
Publicado: (2011)

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
por: Mobbs, Jesse I., et al.
Publicado: (2021)

Phase-plate cryo-EM structure of a class B GPCR-G protein complex
por: Liang, Yi-Lynn, et al.
Publicado: (2017)

CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons
por: Rees, Tayla A., et al.
Publicado: (2022)

Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma
por: Gupta, Pragya, et al.
Publicado: (2020)

Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases
por: Sonne, Nina, et al.
Publicado: (2020)

The Impact of Exposure Profile on the Efficacy of Dual Amylin and Calcitonin Receptor Agonist Therapy
por: Sonne, Nina, et al.
Publicado: (2022)

Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy
por: Wookey, Peter, et al.
Publicado: (2021)

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs
por: Woolley, Michael J., et al.
Publicado: (2017)

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M(4) mAChR
por: Burger, Wessel A. C., et al.
Publicado: (2023)

Agonist bias and agonist‐dependent antagonism at corticotrophin releasing factor receptors
por: Tasma, Zoe, et al.
Publicado: (2020)

The calcitonins : physiology and pharmacology /
por: Azria, M. (Moíse), 1936-
Publicado: (1989)

A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death
por: Furness, SGB, et al.
Publicado: (2016)

Oral calcitonin
por: Hamdy, Ronald C, et al.
Publicado: (2012)

Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis
por: Kauther, Max D, et al.
Publicado: (2011)

The Calcitonin/Calcitonin Gene-Related Peptide Family in Invertebrate Deuterostomes
por: Sekiguchi, Toshio
Publicado: (2018)

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies
por: Vohra, Shabana, et al.
Publicado: (2013)

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology
por: Watkins, H A, et al.
Publicado: (2014)

The dual amylin and calcitonin receptor agonist KBP-089 and the GLP-1 receptor agonist liraglutide act complimentarily on body weight reduction and metabolic profile
por: Larsen, Anna Thorsø, et al.
Publicado: (2021)

The GlyR Extracellular β8–β9 Loop – A Functional Determinant of Agonist Potency
por: Janzen, Dieter, et al.
Publicado: (2017)

Pharmacology and Desensitisation of the Human RAMP3 and Rat Calcitonin Receptor-Like Receptor Combination
por: Hay, D. L., et al.
Publicado: (2001)

Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics
por: Miller, Laurence J., et al.
Publicado: (2021)

Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM
por: Piper, Sarah J., et al.
Publicado: (2022)

Calcitonin-responsive adenylate cyclase in a calcitonin-producing human cancer cell line.
por: Hunt, N. H., et al.
Publicado: (1977)

Cannot write session to /tmp/vufind_sessions/sess_bgn76s17p00v0ici2gofuka740