Neuromodulatory Effect of Thymoquinone in Attenuating Glutamate-Mediated Neurotoxicity Targeting the Amyloidogenic and Apoptotic Pathways

Overexposure of the glutamatergic N-methyl-d-aspartate (NMDA) receptor to the excitatory neurotransmitter l-glutamic acid leads to neuronal cell death by excitotoxicity as a result of increased intracellular Ca(2+), mitochondrial dysfunction, and apoptosis. Moreover, it was previously reported that...

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Detalles Bibliográficos
Autores principales: Fouad, Ibram Amin, Sharaf, Nadia Mohamed, Abdelghany, Ragwa Mansour, El Sayed, Nesrine Salah El Dine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908889/
https://www.ncbi.nlm.nih.gov/pubmed/29706929
http://dx.doi.org/10.3389/fneur.2018.00236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908889/
https://www.ncbi.nlm.nih.gov/pubmed/29706929
http://dx.doi.org/10.3389/fneur.2018.00236

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