Enabling multiplexed testing of pooled donor cells through whole-genome sequencing

We describe a method that enables the multiplex screening of a pool of many different donor cell lines. Our method accurately predicts each donor proportion from the pool without requiring the use of unique DNA barcodes as markers of donor identity. Instead, we take advantage of common single nucleo...

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Detalles Bibliográficos
Autores principales: Chan, Yingleong, Chan, Ying Kai, Goodman, Daniel B., Guo, Xiaoge, Chavez, Alejandro, Lim, Elaine T., Church, George M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909281/
https://www.ncbi.nlm.nih.gov/pubmed/29673390
http://dx.doi.org/10.1186/s13073-018-0541-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909281/
https://www.ncbi.nlm.nih.gov/pubmed/29673390
http://dx.doi.org/10.1186/s13073-018-0541-6

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