Dominant-negative SMARCA4 missense mutations alter the accessibility landscape of tissue-unrestricted enhancers

Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. Unfortunately, the effects of SMARCA4 missense mutations have remained uncertain. Here we show that SMARCA4 cancer missense mutations target conserved ATPase...

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Detalles Bibliográficos
Autores principales: Hodges, H. Courtney, Stanton, Benjamin Z., Cermakova, Katerina, Chang, Chiung-Ying, Miller, Erik L., Kirkland, Jacob G., Ku, Wai Lim, Veverka, Vaclav, Zhao, Keji, Crabtree, Gerald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909405/
https://www.ncbi.nlm.nih.gov/pubmed/29323272
http://dx.doi.org/10.1038/s41594-017-0007-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909405/
https://www.ncbi.nlm.nih.gov/pubmed/29323272
http://dx.doi.org/10.1038/s41594-017-0007-3

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