Oxidative stress increases M(1)dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA

Reactive oxygen species (ROS) are formed in mitochondria during electron transport and energy generation. Elevated levels of ROS lead to increased amounts of mitochondrial DNA (mtDNA) damage. We report that levels of M(1)dG, a major endogenous peroxidation-derived DNA adduct, are 50–100-fold higher...

Descripción completa

Detalles Bibliográficos
Autores principales: Wauchope, Orrette R, Mitchener, Michelle M, Beavers, William N, Galligan, James J, Camarillo, Jeannie M, Sanders, William D, Kingsley, Philip J, Shim, Ha-Na, Blackwell, Thomas, Luong, Thong, deCaestecker, Mark, Fessel, Joshua P, Marnett, Lawrence J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909422/
https://www.ncbi.nlm.nih.gov/pubmed/29438559
http://dx.doi.org/10.1093/nar/gky089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909422/
https://www.ncbi.nlm.nih.gov/pubmed/29438559
http://dx.doi.org/10.1093/nar/gky089

Ejemplares similares