Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides

Chemically modified antisense oligonucleotides (ASOs) with phosphorothioate (PS) linkages have been extensively studied as research and therapeutic agents. PS-ASOs can enter the cell and trigger cleavage of complementary RNA by RNase H1 even in the absence of transfection reagent. A number of cell s...

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Detalles Bibliográficos
Autores principales: Wang, Shiyu, Allen, Nickolas, Vickers, Timothy A, Revenko, Alexey S, Sun, Hong, Liang, Xue-hai, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909429/
https://www.ncbi.nlm.nih.gov/pubmed/29514240
http://dx.doi.org/10.1093/nar/gky145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909429/
https://www.ncbi.nlm.nih.gov/pubmed/29514240
http://dx.doi.org/10.1093/nar/gky145

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