RNA–DNA hybrids promote the expansion of Friedreich's ataxia (GAA)(n) repeats via break-induced replication

Expansion of simple DNA repeats is responsible for numerous hereditary diseases in humans. The role of DNA replication, repair and transcription in the expansion process has been well documented. Here we analyzed, in a yeast experimental system, the role of RNA–DNA hybrids in genetic instability of...

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Detalles Bibliográficos
Autores principales: Neil, Alexander J, Liang, Miranda U, Khristich, Alexandra N, Shah, Kartik A, Mirkin, Sergei M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909440/
https://www.ncbi.nlm.nih.gov/pubmed/29447396
http://dx.doi.org/10.1093/nar/gky099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909440/
https://www.ncbi.nlm.nih.gov/pubmed/29447396
http://dx.doi.org/10.1093/nar/gky099

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